Temporal pa ern of the induction of SF-1 gene expression by the sig- nal transduction pathway involving 3’,5’-cyclic adenosine monophos- phate
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چکیده
important role in the maintenance of the differentiated functions of these organs, and is essential for the expression of all steroidogenic CYPs (Parker & Schimmer, 1997). It is also required for the expression of other genes involved in steroid hormone synthesis such as steroidogenic acute regulatory protein (StAR), 3β-hydroxysteroid dehydrogenase /Δ5-Δ4 isomerase (HSD3B) and the ACTH receptor (ACTH-R, melanocortin-2 receptor MC2R) (Hammer & Ingraham, 1999). SF-1 has also been linked to the regulation of target gene expression in response to tropic hormones acting via the cAMP/protein kinase A (PKA) pathway. SF-1 has been shown to take part in cAMP-induced expression of StAR (Wooton-Kee & Clark, 2000), P450scc (CYP11A1) (Liu & Simpson, Temporal pa ern of the induction of SF-1 gene expression by the signal transduction pathway involving 3’,5’-cyclic adenosine monophosphate
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